Prostasin, a potential tumor marker in ovarian cancer: a pilot study
Clinics
;
64(7): 641-644, 2009.
Artigo
em Inglês
| LILACS
| ID: lil-520795
ABSTRACT
INTRODUCTION:
Ovarian cancer is generally diagnosed at advanced stages of the disease; therefore, poor prognoses are typical. The development of tumor markers is thus of utmost importance. Prostasin is a protease that in normal tissues is highly expressed only in the prostate gland and seminal fluid. A previous study showed that prostasin is highly overexpressed in ovarian cancer cell lines. This study sought to evaluate the expression of prostasin in ovarian cancer.METHODS:
Fresh tumor samples of ovarian epithelial cancer (n 12) were analyzed for expression of prostasin mRNA (messenger ribonucleic acid) by conventional and real time quantitative PCR (polymerase chain reaction). As a standard control, a normal prostate sample was analyzed.RESULTS:
Using conventional PCR, prostasin was detected in all but one sample. Using quantitative PCR, prostasin was over-expressed in all but one of the samples as compared to the control (prostate).CONCLUSIONS:
These findings indicate that prostasin is overexpressed in many epithelial ovarian cancers. Further studies of prostasin as a potential biomarker for this disease are warranted.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Neoplasias Ovarianas
/
Serina Endopeptidases
/
Biomarcadores Tumorais
/
Regulação Neoplásica da Expressão Gênica
/
Programas de Rastreamento
/
Proteínas de Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Suécia
Instituição/País de afiliação:
Hospital Santa Casa/BR
/
Karolinska University Hospital/SE
/
Pontifícia Universidade Católica do Rio Grande do Sul/BR
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