Protective immunity against Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
104(supl.1): 288-294, July 2009. ilus, graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-520891
ABSTRACT
Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed. Emphasis is placed on recent studies of the important protective role of CD8+ T cells and on previous studies of immunisation of domestic T. cruzi reservoirs that sought to address practical vaccination problems. Research on the maturation of memory cells and studies indicating that the prevalence of T. cruzi-specific T-cell responses and a high frequency of committed CD8+ T cells are associated with better clinical outcomes are also reviewed. Additionally, animal models in which protection was achieved without immunopathological consequences are discussed.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Anticorpos Antiprotozoários
/
Vacinas Protozoárias
/
Doença de Chagas
Tipo de estudo:
Fatores de risco
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad Nacional de Salta/AR
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