Neuro functional and endocrine findings in patients with post-traumatic stress disorder
Rev. med. nucl. Alasbimn j
;
11(44)apr. 2009. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-522222
ABSTRACT
The authors studied the neuro-functional findings demonstrated by SPECT in a group of 7 patients diagnosed with post traumatic stress disorder (PTSD) and their correlation with endocrinologic and clinical variables. Brain perfusion was assessed using SPECT Tc99m ECD. The Davidson Trauma Scale (DTS) for post traumatic stress disorder and the abbreviated version of the Beck Depression Inventory (BDI) were used to corroborate clinical impressions. Endocrine measures included T3, total T4, TSH and cortisol levels. Neuro-functional findings included abnormal radiopharmaceutical uptake in regions involved in the recovery of verbal memories and executive functions (frontal and pre-frontal cortex), and limbic system. No endocrine alterations affecting thyroid or cortisol levels were found. The broad distribution of neuro-functional abnormalities causes us to hypothesize a diffuse etiologic mechanism, possibly involving a dysfunction in the permeability of the blood-brain barrier due to an underlying inflammatory process.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Transtornos de Estresse Pós-Traumáticos
/
Compostos de Organotecnécio
/
Tomografia Computadorizada de Emissão de Fóton Único
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. med. nucl. Alasbimn j
Assunto da revista:
Medicina Nuclear
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Chile
/
Estados Unidos
Instituição/País de afiliação:
Clinica Las Condes/CL
/
Hospital Dipreca/CL
/
Psychiatric Society of Chile/CL
/
University of California/US
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