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Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats
Mahn, Andrea V; Toledo, Héctor M; Ruz, Manuel H.
  • Mahn, Andrea V; Universidad de Santiago de Chile. Departamento de Ingeniería Química. CL
  • Toledo, Héctor M; Universidad de Chile. Facultad de Medicina. Instituto de Ciencias Biomédicas. Programa de Biología Celular y Molecular. CL
  • Ruz, Manuel H; Universidad de Chile. Facultad de Medicina. Departamento de Nutrición. CL
Biol. Res ; 42(2): 163-173, 2009. ilus, tab, graf
Artigo em Inglês | LILACS | ID: lil-524886
ABSTRACT
Some selenium compounds offer important health benefits when administered at supranutritional doses, such as improvement of the immune system and of male fertility, and the prevention of some types of cancer. The traditional selenium indexes do not account for the metabolic status of this element among replete individuals. As a consequence, there is a need for new indexes that distinguish between repletion statuses of selenium. The aim of this work was to indentify some plasmatic proteins that respond to supranutritional doses of selenium, which could be proposed as new protein markers of selenium intake. The effect on rats of dietary supplementation with either selenomethylselenocysteine (SMSeC) or sodium-selenate on some blood plasma proteins was investigated. Two experimental groups consisting of six rats each were fed a basic diet supplemented with either SMSeC or sodium-selenate at 1.9 mg-Se / g-diet for ten weeks. The control group was fed a diet that contained the recommended selenium dose (0.15 mg-Se / g-diet). The changes in the abundance of a group of plasmatic proteins were quantified and analysed statistically. Haptoglobin, apolipoprotein E and transthyretin increased their abundance after diet supplementation with either form of selenium. HNF6 was responsive only to SMSeC, whereas fibrinogen responded only to sodium-selenate. We postulate that the protein patterns observed in this work could be proposed as new molecular biology-based markers of selenium intake.
Assuntos

Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Selênio / Proteínas Sanguíneas / Compostos Organosselênicos / Compostos de Selênio / Suplementos Nutricionais / Cisteína Limite: Animais Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2009 Tipo de documento: Artigo / Documento de projeto País de afiliação: Chile Instituição/País de afiliação: Universidad de Chile/CL / Universidad de Santiago de Chile/CL

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Selênio / Proteínas Sanguíneas / Compostos Organosselênicos / Compostos de Selênio / Suplementos Nutricionais / Cisteína Limite: Animais Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2009 Tipo de documento: Artigo / Documento de projeto País de afiliação: Chile Instituição/País de afiliação: Universidad de Chile/CL / Universidad de Santiago de Chile/CL