In vitro antiplasmodial activity and toxicity assessment of plant extracts used in traditional malaria therapy in the Lake Victoria Region
Mem. Inst. Oswaldo Cruz
;
104(5): 689-694, Aug. 2009. tab
Artigo
em Inglês
| LILACS
| ID: lil-528074
ABSTRACT
As part of our program screening the flora of the Lake Victoria Region, a total of 54 organic extracts from seven plant families (8 species) were individually tested for antiplasmodial activity against chloroquine-sensitive [Sierra Leone (D-6)] and chloroquine-resistant [Vietnam (W-2)] strains. Only 22 percent of these extracts exhibited very high in vitro antiplasmodial activity. Six methanol (MeOH) extracts and one chloroform extract showed in vitro antiplasmodial activity against the D-6 Plasmodium falciparum strain, while only three MeOH extracts were active against the W-2 strain. All of the ethyl acetate extracts proved to be inactive against both strains of P. falciparum. A brine shrimp cytotoxicity assay was used to predict the potential toxicity of the extracts. The cytotoxicity to antiplasmodial ratios for the MeOH extracts were found to be greater than 100, which could indicate that the extracts are of low toxicity.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plantas Medicinais
/
Plasmodium falciparum
/
Artemia
/
Extratos Vegetais
/
Antimaláricos
Limite:
Animais
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Quênia
/
Ruanda
Instituição/País de afiliação:
Jomo Kenyatta University of Agriculture and Technology/KE
/
Kenyatta University/KE
/
Kigali Institute of Science and Technology/RW
Similares
MEDLINE
...
LILACS
LIS