Postantibiotic effects and postantibiotic sub-MIC effects of tilmicosin, erythromycin and tiamulin on erythromycin-resistant Streptococcus suis
Braz. j. microbiol
;
40(4): 980-987, Oct.-Dec. 2009. tab
Artigo
em Inglês
| LILACS
| ID: lil-528188
ABSTRACT
The postantibiotic effects (PAEs) and postantibiotic sub-MIC effects (PA SMEs) of tilmicosin, erythromycin and tiamulin on erythromycin-susceptible and erythromycin-resistant strains of Streptococcus suis (M phenotype) were investigated in vitro. Tilmicosin and tiamulin induced significantly longer PAE and PA SME against both erythromycin-susceptible and erythromycin-resistant strains than did erythromycin. The durations of PAE and PA SMEs were proportional to the concentrations of drugs used for exposure. The PA SMEs were substantially longer than PAEs on S. suis (P<0.05) regardless of the antimicrobial used for exposure. The results indicated that the PAE and PA SME could help in the design of efficient control strategies for infection especially caused by erythromycin-resistant S. suis and that they may provide additional valuable information for the rational drug use in clinical practice.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Infecções Estreptocócicas
/
Suínos
/
Técnicas In Vitro
/
Resistência Microbiana a Medicamentos
/
Streptococcus suis
/
Suscetibilidade a Doenças
/
Antibacterianos
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. microbiol
Assunto da revista:
Microbiologia
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Nanjing Agricultural University/CN
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