Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies
Mem. Inst. Oswaldo Cruz
;
104(6): 862-864, Sept. 2009. ilus
Artigo
em Inglês
| LILACS
| ID: lil-529555
ABSTRACT
The primary culture of intestinal epithelial cells from domestic cats is an efficient cellular model to study the enteric cycle of Toxoplasma gondii in a definitive host. The parasite-host cell ratio can be pointed out as a decisive factor that determines the intracellular fate of bradyzoites forms. The development of the syncytial-like forms of T. gondii was observed using the 120 bradyzoite-host cell ratio, resulting in similar forms described in in vivo systems. This alternative study potentially opens up the field for investigation into the molecular aspects of this interaction. This can contribute to the development of new strategies for intervention of a main route by which toxoplasmosis spreads.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Toxoplasma
/
Células Epiteliais
/
Interações Hospedeiro-Parasita
/
Mucosa Intestinal
/
Estágios do Ciclo de Vida
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Instituto Oswaldo Cruz-Fiocruz/BR
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