Schizophrenia is not associated with the ERBB3 gene in a Han Chinese population sample: results from case-control and family-based studies

Li, Dawei; He, Guang; Xu, Yifeng; Duan, Yun; Gu, Niufan; Li, Xingwang; Shi, Yongyong; Qin, Wei; Feng, Guoyin; He, Lin

Li, Dawei; He, Guang; Xu, Yifeng; Duan, Yun; Gu, Niufan; Li, Xingwang; Shi, Yongyong; Qin, Wei; Feng, Guoyin; He, Lin.

Li, Dawei; Shanghai Jiao Tong University. Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders. Bio-X Center. Shanghai. CN
He, Guang; Shanghai Jiao Tong University. Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders. Bio-X Center. Shanghai. CN
Xu, Yifeng; Shanghai Institute of Mental Health. Shanghai. CN
Duan, Yun; Chinese Academy of Sciences. Shanghai Institute of Biological Sciences. Institute for Nutritional Sciences. Shanghai. CN
Gu, Niufan; Shanghai Institute of Mental Health. Shanghai. CN
Li, Xingwang; Shanghai Jiao Tong University. Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders. Bio-X Center. Shanghai. CN
Shi, Yongyong; Shanghai Jiao Tong University. Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders. Bio-X Center. Shanghai. CN
Qin, Wei; Shanghai Jiao Tong University. Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders. Bio-X Center. Shanghai. CN
Feng, Guoyin; Shanghai Institute of Mental Health. Shanghai. CN
He, Lin; Shanghai Jiao Tong University. Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders. Bio-X Center. Shanghai. CN

Genet. mol. biol ; 32(4): 729-730, 2009. tab

Artigo em Inglês | LILACS | ID: lil-531815

ABSTRACT

ABSTRACT

ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3), encoding a receptor of neuregulin-1 (NRG1), has been considered a functional candidate gene for schizophrenia susceptibility. In order to investigate a relationship between ERBB3 gene and schizophrenia in the Chinese population, case-control and family-based studies were carried out in 470 cases matched by controls, and in 532 family trios. Our results failed to show any evidence of significant association between the ERBB3 rs2292238 polymorphism and schizophrenia.

ERBB3 gene; Schizophrenia

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Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Revista: Genet. mol. biol Assunto da revista: Genética Ano de publicação: 2009 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Chinese Academy of Sciences/CN / Shanghai Institute of Mental Health/CN / Shanghai Jiao Tong University/CN

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