Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia
Biol. Res
;
42(3): 281-287, 2009. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-531961
ABSTRACT
Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind placebo controlled study for 4 months. The treated group received 100 mg/day of isoflavones. Blood collections were conducted on three different occasions to assess total glutathione; superoxide dismutase and catalase in erythrocytes; lipid peroxidation; and homocysteine plasma concentrations. No differences between the groups were observed. However, all the patients seem to improve their oxidative stress status and homocysteine concentration after treatment. Superoxide dismutase activity was correlated with age and time of menopause at the beginning of the treatment, but these correlations were no longer observed by the end of the study. Soy isoflavones were not able to overcome the placebo effect for either oxidative stress parameters or homocysteine concentrations.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pós-Menopausa
/
Estresse Oxidativo
/
Proteínas de Soja
/
Homocisteína
/
Distúrbios do Início e da Manutenção do Sono
/
Isoflavonas
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de São Paulo (UNIFESP-EPM)/BR
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