Sistema hipocretinérgico y narcolepsia / Hypocretin system and narcolepsy
Rev. méd. Chile
;
137(9): 1209-1216, sep. 2009. tab, ilus
Artigo
em Espanhol
| LILACS
| ID: lil-534025
ABSTRACT
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep-onset rapid eye movement (REM) sleep periods. It is now identified as a neurodegenerative disease because there is a massive loss of specific neurons in the brain. These neurons contain the neuropeptides hypocretin-1 and hypocretin-2, which are also known as orexin-A and orexin-B. Cerebrospinal fluid hypocretin-1 measurements are diagnostic for primary narcolepsy. The cause of neural loss could be autoinmune since most patients have the HLA DQB1*0602 alíele that predisposes to the disorders. The discovery of hypocretin deficiency is redefining the clinical entity of narcolepsy and offering novel diagnostic procedures. This article reviews the current understanding of narcolepsy and discusses the implications of hypocretin discovery (Rev Méd Chile 2009; 1371209-16).
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Neuropeptídeos
/
Narcolepsia
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Alemanha
Instituição/País de afiliação:
Philipps-Universitat Marburg/DE
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