Infecciones en pacientes con lupus eritematoso sistémico / Infections in patients with systemic lupus erythematosus
Rev. méd. Chile
;
137(10): 1367-1374, oct. 2009.
Artigo
em Espanhol
| LILACS
| ID: lil-534046
ABSTRACT
Despite the availability of newer therapeutic interventions to improve clinical outcome in patients with Systemic Lupus Erythematosus (SLE), the incidence of infections as a cause of morbidity and mortality has not changed over the past 30 years. SLE itself increases the risk of infection, due to genetic (complement deficiencies) and acquired factors such as functional asplenia (humoral immunodepression) and the use of immunosuppressive drugs. These medications increase the risk of opportunistic infections that are associated with an altered cellular immune response. The main etiologic infectious agents in SLE patients are common bacterial pathogens, especially capsulated ones. The most common sites are lung, skin, bladder, brain and systemic infections. The main risk factor for infection is the history of a previous one. The clinical approach to SLE patients with suspected infectious diseases must consider the possibility of a flare up of the underlying disease, posing an additional problem to the clinician.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Chile
/
Portugal
Instituição/País de afiliação:
Servicio de Salud Metropolitano Norte/CL
/
Universidad de Los Andes/CL
/
Universidad de los Andes/CL
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