Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection
Mem. Inst. Oswaldo Cruz
;
104(8): 1063-1071, Dec. 2009. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-538165
ABSTRACT
Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration when compared to BALB/c mice. However, all mice from both lineages die in the early acute phase. Therefore, in this work we studied the physiological connection relating arterial pressure, renal function/damage and cardiac insufficiency as causes of death. Our results show that a broader set of dysfunctions that could be classified as a cardio/anaemic/renal syndrome is more likely responsible for cardiac failure and death in both lineages. However, gld/gld mice had very early glomerular deposition of IgM and a more intense renal inflammatory response with reduced renal filtration, which is probably responsible for the premature death in the absence of significant myocarditis in gld/gld.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doença de Chagas
/
Proteína Ligante Fas
/
Injúria Renal Aguda
/
Miocardite
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Centro de Criação de Animais de Laboratório/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
/
Universidade Federal Fluminense/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Federal do Rio de Janeiro/BR
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