Pathogenic and opportunistic respiratory bacteria-induced apoptosis
Braz. j. infect. dis
;
13(3): 226-231, June 2009. ilus
Artigo
em Inglês
| LILACS
| ID: lil-538525
ABSTRACT
Several pathogenic or opportunistic bacteria have the ability to either induce or inhibit host cell apoptosis. The capacity to modulate cell pathways that result in the induction or delay of host cell apoptosis is considered to be an important bacterial virulence mechanism. These processes could be mediated by different host cell signaling pathways that are subverted by the bacteria. Pathogens are able to activate apoptotic proteins, such as caspases, or inactivate anti-apoptotic proteins, such as NFkB and the MAPKKs, or even up-regulate the endogenous receptor/ligand system that induces apoptosis, generally when the bacteria are bound to the host cell surface. The bacteria-induced apoptotic or anti-apoptotic processes are often related with the fact that the bacteria acquire the ability to reach the host tissues. However, apoptosis is also considered to be a host defense mechanism against infectious agents. Thus, the apoptosis phenomenon plays a central role in host-pathogen interactions.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Apoptose
/
Interações Hospedeiro-Patógeno
/
Bactérias Gram-Negativas
/
Bactérias Gram-Positivas
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2009
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
State University of Campinas/BR
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