Cell-mediated immune response to Leishmania chagasi experimental infection of BALB/c immunosuppressed mice
J. venom. anim. toxins incl. trop. dis
;
16(1): 131-146, 2010. graf
Artigo
em Inglês
| LILACS
| ID: lil-542426
ABSTRACT
Leishmaniasis, a zoonosis of worldwide distribution, presents a significant impact on immunosupressed patients. This study aimed to evaluate Leishmania chagasi infection in BALB/c mice immunosuppressed with dexamethasone. Spleen cells stimulated or not with L. chagasi were cultured for cytokine quantification (IFN-gama, IL-2, IL-4 and IL-10) by sandwich ELISA. Parasite loads in the spleen and liver were determined by means of culture microtitration. Immunosuppressed groups showed statistically lower spleen weight and CD4-cell percentage in blood on the day of infection and produced Th1 and Th2 cytokines on other days of the study. The other infected groups, weather immunosupressed or not, also produced Th1 and Th2 cytokines. Parasite loads in the spleen and liver were not statistically different among the groups. It was concluded that L. chagasi infection was not affected by dexamethasone-induced immunosuppression, probably due the reversible effect of the treatment.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Terapia de Imunossupressão
/
Imunidade Celular
/
Leishmaniose Visceral
/
Camundongos Endogâmicos BALB C
Limite:
Animais
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2010
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
São Paulo State Universit/BR
/
São Paulo State University/BR
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