ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
J. venom. anim. toxins incl. trop. dis
;
16(1): 87-95, 2010. tab
Artigo
em Inglês
| LILACS
| ID: lil-542431
ABSTRACT
Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4 percent (n = 73) tested positive and 33.6 percent (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0 percent) compared with chronic active gastritis (n = 52; 61.2 percent) (p = 0.05; OR 3.332; 95 percent CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2 percent) compared with other ABO phenotypes (25/47; 53.2 percent) (p = 0.01; OR 2.816; 95 percent CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Úlcera Péptica
/
Sistema ABO de Grupos Sanguíneos
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Gastrite
Tipo de estudo:
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2010
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Fundação Faculdade Regional de Medicina Funfarme/BR
/
Regional Medical School Foundation/BR
/
São José do Rio Preto Medical School/BR
/
São Paulo State University/BR
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