Analgesic efficacy and safety of nonsteroidal anti-inflammatory drugs after transurethral resection of prostate
Int. braz. j. urol
;
36(1): 49-54, Jan.-Feb. 2010. graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-544074
ABSTRACT
Objectives:
The aim of this study was to assess the analgesic efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAIDs), administered as intramuscular diclofenac in comparison with intravenous paracetamol after transurethral resection of the prostate (TURP). Materials andmethods:
Fifty men, aged 55 to 75 years, undergoing TURP at our hospital were included in this study. Patients were divided randomly and prospectively into two groups (25 patients in each group). Group I (NSAID) received 75 mg of diclofenac i.m. at the end of the operation followed by 75 mg of diclofenac i.m. for 24 hours (75 mg x 2 once a day = 150 mg/24 h) postoperatively. The other group (Group II) consisted of patients who received 1g/100 mL i.v. paracetamol 15 minutes twice daily as postoperative analgesia. Postoperative pain scores were evaluated at 30 minutes, 1, 2, 4 and 6 hours after administration of each analgesic, using a visual analogue scale (VAS). Furthermore, preoperative and postoperative hemoglobin (Hb) levels and hemostatic variables (bleeding time, prothrombine time and the international normalized ratio?, i.e. the ratio of a patient's prothrombin time to a normal [control] sample) were recorded in all patients.Results:
The pain score changes during a 4 hour period between the two groups was similar (p = 0.162). Thirty minutes after surgery, pain scores were high (> 3 cm) in both groups and without differences between groups (p = 0.11) but 6 hours after surgery, pain scores were significantly higher with paracetamol compared to diclofenac (p < 0.05). No significant difference was observed between the groups regarding the amount of resected tissue, operating time, preoperative-postoperative Hb levels and hemostatic variables. In the both groups, no patient required blood transfusion postoperatively.Conclusions:
NSAIDs are not a contraindication to TURP and should be used for the control of postoperative pain if indicated.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Dor Pós-Operatória
/
Anti-Inflamatórios não Esteroides
/
Diclofenaco
/
Ressecção Transuretral da Próstata
/
Acetaminofen
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Kecioren Training and Research Hospital/TR
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