Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile / Salivary cortisol among subjects with and without Cushing syndrome
Rev. méd. Chile
;
138(2): 168-174, feb. 2010. tab, ilus
Artigo
em Espanhol
| LILACS
| ID: lil-546207
ABSTRACT
Background:
Salivary cortisol measurement is recommended as a screening mea-sure when a Cushing Syndrome is suspected. Theproposed cut-offpointfor aprobable diagnosis is 0.16 ug/dL.Aim:
To determine salivary cortisol concentrations during the day inpatients with and without Cushing syndrome and with depression. Material andMethods:
Salivary cortisol was measured by competitive enzyme immuno assay (EIA), in samples obtained at 800,1500 and 2300 h in 78 patients without Cushing syndrome, aged 40 ± 15years (28 males), 30 patients with depression aged 40 ± 12years (nine males) and four jemales with Cushing syndrome aged 42 ± 17 years.Results:
Salivary cortisol was higher among patients with Cushing syndrome than the rest of patients. A salivary cortisol over the cut-off value of O.16 ug/dL was found in 42 percent of subjects without Cushing syndrome and in 33 percent of patients with depression. Median values among patients without Cushing syndrome, depression and with Cushing syndrome were 0.21 (range < 0.1-1.42), 0.2 (range 0,12-0.9) and 0.58 (range 0.37-1.1) ug/dL, respectivelyConclusions:
Salivary cortisol measured by EIA method was higher among patients with Cushing syndrome but there was a great overlap with values obtained in subjects without the syndrome.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Saliva
/
Hidrocortisona
/
Ritmo Circadiano
/
Síndrome de Cushing
/
Depressão
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2010
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Hospital Clínico de la Universidad de Chile/CL
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