Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease
Clinics
;
65(4): 383-387, 2010. tab
Artigo
em Inglês
| LILACS
| ID: lil-546312
ABSTRACT
OBJECTIVES:
To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease.METHOD:
Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test.RESULTS:
There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations.CONCLUSIONS:
Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doenças Vasculares Periféricas
/
Aterosclerose
/
Índice Tornozelo-Braço
/
Lipoproteínas LDL
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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