Metabolic profile and cardiovascular risk factors among Latin American HIV-infected patients receiving HAART
Braz. j. infect. dis
;
14(2): 158-166, Mar.-Apr. 2010. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-548461
ABSTRACT
OBJECTIVE:
Determine the prevalence of metabolic abnormalities (MA) and estimate the 10-year risk for cardiovascular disease (CVD) among Latin American HIV-infected patients receiving highly active anti-retroviral therapy (HAART).METHODS:
A cohort study to evaluate MA and treatment practices to reduce CVD has been conducted in seven Latin American countries. Adult HIV-infected patients with at least one month of HAART were enrolled. Baseline data are presented in this analysis.RESULTS:
A total of 4,010 patients were enrolled. Mean age (SD) was 41.9 (10) years; median duration of HAART was 35 (IQR 10-51) months, 44 percent received protease inhibitors. The prevalence of dyslipidemia and metabolic syndrome was 80.2 percent and 20.2 percent, respectively. The overall 10-year risk of CVD, as measured by the Framingham risk score (FRF), was 10.4 (24.7). Longer exposure to HAART was documented in patients with dyslipidemia, metabolic syndrome and type 2 diabetes mellitus. The FRF score increased with duration of HAART. Male patients had more dyslipidemia, high blood pressure, smoking habit and higher 10-year CVD than females.CONCLUSIONS:
Traditional risk factors for CVD are prevalent in this setting leading to intermediate 10-year risk of CVD. Modification of these risk factors through education and intervention programs are needed to reduce CVD.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doenças Cardiovasculares
/
Infecções por HIV
/
Fármacos Anti-HIV
/
Terapia Antirretroviral de Alta Atividade
/
Doenças Metabólicas
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Brasil
/
Colômbia
/
Peru
/
Estados Unidos
/
Venezuela
Instituição/País de afiliação:
Bristol-Myers Squibb, Research and Development/BR
/
Bristol-Myers Squibb, Research and Development/US
/
Cayetano Heredia Peruvian University/PE
/
Cecília Grierson Foundation/AR
/
Center of Clinical Immunology/VE
/
Central University/VE
/
Faculdade de Medicina do ABC/BR
/
Huésped Foundation/AR
/
Prefeitura de Porto Alegre/BR
/
Unisánitas Department of Infectious Diseases/CO
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