Vancomycin: the need to suit serum concentrations in hemodialysis patients
Braz. j. infect. dis
;
14(2): 203-208, Mar.-Apr. 2010. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-548467
ABSTRACT
The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several have not been conducted with current dialyzers. This study aimed at assessing the suitability of vancomycin serum concentrations in HD patients at a public hospital. Blood samples of HD patients were collected from November 2006 to May 2007, at time intervals of 48, 96, 120, or 168 hours after vancomycin administration. Drug measurement was performed with polarized light immunofluorescence. Approximately 86 percent of trough vancomycin serum concentrations were below the recommended value, indicating exposure to subtherapeutic doses and a higher risk for selecting resistant microorganisms.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vancomicina
/
Diálise Renal
/
Antibacterianos
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2010
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Conjunto Hospitalar de Sorocaba/BR
/
PUC/BR
/
Universidade de Sorocaba/BR
Similares
MEDLINE
...
LILACS
LIS