Quality-of-Life assessment and clinical-laboratory response to use of the combination of menthol, guaiacol, terpineol, eucalyptol, gomenol, and camphor in patients presenting persistent cough / Avaliação da qualidade de vida e resposta clínico-laboratorial ao uso da associação de mentol, guaiacol, terpinol, eucaliptol, gomenol e cânfora em pacientes apresentando tosse persistente

ABSTRACT

We evaluated the use of a combination of menthol, guaiacol, terpineol, eucalyptol, gomenol, and camphor injection in patients presenting persistent cough who were submitted to a 7-day treatment regimen with daily doses of the medication and a series of clinical and laboratory evaluations, including a quality-of-life questionnaire, spirometry, and assessments of overall condition by the patient and the physician, performed prior to the first dose of medication, after three days of treatment, and at the end of the 7-day treatment period. The use of concomitant medications and the incidence, severity and duration of adverse events were also evaluated. A total of sixty-one patients were included in the study. There were no clinically significant changes in vital signs, laboratory tests, or spirometry throughout the treatment period. A statistically significant improvement (p<0.0001) in the assessments of overall condition by the patient and physician was observed, and there was a statistically significant improvement in the scores of the quality-of-life questionnaire (p<0.0001). While adverse events were recorded, none were serious and all were resolved by the end of the treatment period. Based on the results of this study, we conclude that the combination of menthol, guaiacol, terpineol, eucalyptol, gomenol, and camphor in the form of an intramuscular injection was safe and effective ameliorating the effects of persistent cough in the quality of life of the patient population evaluated.