Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
Braz. oral res
;
24(2): 170-176, Apr.-June 2010. ilus
Artigo
em Inglês
| LILACS
| ID: lil-553903
ABSTRACT
Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Tíbia
/
Regeneração Óssea
/
Consolidação da Fratura
/
Hipertensão
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. oral res
Assunto da revista:
Odontologia
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Guarulhos University/BR
/
Nove de Julho University/BR
Similares
MEDLINE
...
LILACS
LIS