Norepinephrine remains increased in the six-minute walking test after heart transplantation
Clinics
;
65(6): 587-591, 2010. tab
Artigo
em Inglês
| LILACS
| ID: lil-553964
ABSTRACT
OBJECTIVE:
We sought to evaluate the neurohormonal activity in heart transplant recipients and compare it with that in heart failure patients and healthy subjects during rest and just after a 6-minute walking test.INTRODUCTION:
Despite the improvements in quality of life and survival provided by heart transplantation, the neurohormonal profile is poorly described.METHODS:
Twenty heart transplantation (18 men, 49±11 years and 8.5±3.3 years after transplantation), 11 heart failure (8 men, 43±10 years), and 7 healthy subjects (5 men 39±8 years) were included in this study. Blood samples were collected immediately before and during the last minute of the exercise.RESULTS:
During rest, patients' norepinephrine plasma level (659±225 pg/mL) was higher in heart transplant recipients (463±167 pg/mL) and heathy subjects (512±132), p<0.05. Heart transplant recipient's norepinephrine plasma level was not different than that of healthy subjects. Just after the 6-minute walking test, the heart transplant recipient's norepinephrine plasma level (1248±692 pg/mL) was not different from that of heart failure patients (1174±653 pg/mL). Both these groups had a higher level than healthy subjects had (545±95 pg/mL), p<0.05.CONCLUSION:
Neurohormonal activity remains increased after the 6-minute walking test after heart transplantation.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Norepinefrina
/
Caminhada
/
Transplante de Coração
/
Teste de Esforço
/
Insuficiência Cardíaca
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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