Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application: [review]
Int. braz. j. urol
;
36(3): 273-282, May-June 2010.
Artigo
em Inglês
| LILACS
| ID: lil-555186
ABSTRACT
Bladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease. The high frequency of recurrence of noninvasive bladder cancer and poor survival rate of invasive bladder cancer emphasizes the need for novel therapeutic approaches. These mechanisms of tumor development and promotion in bladder cancer are strongly associated with several growth factor pathways including the fibroblast, epidermal, and the vascular endothelial growth factor pathways. In this review, efforts to translate the growing body of basic science research of novel treatments into clinical applications will be explored.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Neoplasias da Bexiga Urinária
/
Receptores de Fatores de Crescimento de Fibroblastos
/
Fator A de Crescimento do Endotélio Vascular
/
Receptores ErbB
Limite:
Humanos
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
University of Colorado Denver/US
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