Colonization by Helicobacter pylori of leprosy patients in Spain: immunomodulation to low molecular weight antigens of H. pylori
Mem. Inst. Oswaldo Cruz
;
105(5): 682-686, Aug. 2010. tab
Artigo
em Inglês
| LILACS
| ID: lil-557230
ABSTRACT
We studied the prevalence of Helicobacter pylori in patients with leprosy and the effects of co-infection on the immune response to Helicobacter antigens in the polar groups of leprosy (lepromatous and tuberculoid). We showed that there is no difference in the prevalence of H. pylori in patients with leprosy as compared to a non-leprosy population. We also demonstrated that the immune response to low molecular weight H. pylori antigens (35, 26 and 19 kDa) differs in patients with lepromatous as compared to those with tuberculoid leprosy. In lepromatous leprosy, we show that there is a higher prevalence of the 35 and 26 kDa antigens, but a lower prevalence of the 19 kDa antigen. These immunological results are consistent with previous histopathological studies illustrating a more severe gastrointestinal inflammation in lepromatous patients; importantly, a response to the 35 kDa antigen is recognized as a marker for the development of ulcerative disease.
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LILACS (Américas)
Assunto principal:
Hanseníase Virchowiana
/
Hanseníase Tuberculoide
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Imunomodulação
/
Gastrite
/
Antígenos de Bactérias
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Europa
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Itália
/
Nigéria
/
Espanha
/
Reino Unido
Instituição/País de afiliação:
Sanatorium San Francisco de Borja/ES
/
University College London Hospital Trust/GB
/
University of Bologna/IT
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