Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis
Braz. j. infect. dis
;
14(4): 335-341, July-Aug. 2010. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-561203
ABSTRACT
BACKGROUND:
This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis.METHODS:
This is a cross-sectional study in which 52 patients were divided into two groups Group 1 patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2 patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system.RESULTS:
Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR > F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8 percent, 83.0 percent, and 70.0 percent, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5 percent, 70.0 percent, and 94.0 percent, respectively.CONCLUSION:
HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hepatite C Crônica
/
Ácido Hialurônico
/
Cirrose Hepática
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2010
Tipo de documento:
Artigo
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