Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
Clinics
;
65(10): 1037-1042, 2010. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-565991
ABSTRACT
INTRODUCTION:
We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae).METHODS:
We used elevated plus maze, spontaneous motor activity and ketamine-induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n-decanal (70.1 percent) and alpha-pinene (12.4 percent) constituted the major components.RESULTS:
In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25-200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine-induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plantas Medicinais
/
Sono
/
Ansiolíticos
/
Óleos de Plantas
/
Aprendizagem em Labirinto
/
Hipnóticos e Sedativos
/
Atividade Motora
Limite:
Animais
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2010
Tipo de documento:
Artigo
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