Estudio de la función endotelial mediante tomografía por emisión de positrones en pacientes con hipercolesterolemia / Endothelial function assessment by positron emission tomography in patients with hypercholesterolemia
Arch. cardiol. Méx
; 78(2): 139-147, abr.-jun. 2008.
Article
em Es
| LILACS
| ID: lil-567654
Biblioteca responsável:
BR1.1
ABSTRACT
Hypercholesterolemia prompts to endothelial dysfunction (ED) and ED predisposes to atherogenesis. ED appears early in the course of atherogenesis and it is considered a coronary artery disease (CAD) marker. OBJECTIVES:
To assess endothelial function (EF) using Positron Emission Tomography (PET) in asymptomatic patients with recent dyslipidemia diagnosis and without history of ischemic heart disease and previous hypolipemiant treatment. MATERIAL ANDMETHODS:
Fourteen asymptomatic patients with recent dyslipidemia diagnosis (< 6 months) were studied by obtaining a lipid profile, blood glucose, and a three phase 13N-ammonia PET scan rest, cold pressor test (CPT) and pharmacologic stress with adenosine. EF was assessed by calculating the coronary flow reserve (CFR), endothelial-dependant vasodilatation index (EDVI), and coronary blood flow increase percentage in CPT (% Delta CF).RESULTS:
79% of patients with dyslipidemia had ED and all their values were lower than those previously published as normal rest coronary flow 0.44 +/- 0.12 vs 0.57 +/- 0.147 (p = 0.002), CPT coronary flow 0.57 +/- 0.17 vs 0.88 +/- 0.26 (p = 0.001), stress coronary flow 1.24 +/- 0.05 vs 1.81 +/- 0.35 (p = 0.005), EDVI 1.28 +/- 0.25 vs 1.53 +/- 0.24 (p 0.017), CRF 2.79 +/- 0.94 vs 3.15 +/- 0.48 (p 0.198) and % Delta CF 29.08 +/- 24.62% vs 53 +/- 24.60% (p 0.022).Conclusions:
Asymptomatic patients in early stages of dyslipidemia showed a greater ED prevalence that was detected by 13N-ammonia PET scan.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Endotélio Vascular
/
Tomografia por Emissão de Pósitrons
/
Hipercolesterolemia
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
Es
Revista:
Arch. cardiol. Méx
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article