Modelo de estudio mediante microPET para la evaluación del metabolismo glucolítico en el miocardio de rata con 18F-FDG. Experiencia inicial en México / A method designed for the assessment of myocardial metabolism in rats with 18F-FDG using small-animal-PET. Initial experience in Mexico
Arch. cardiol. Méx
;
78(1): 11-18, ene.-mar. 2008.
Artigo
em Espanhol
| LILACS
| ID: lil-567787
ABSTRACT
PURPOSE:
To standarize an acquisition protocol for the study of myocardial metabolism in adult rats. MATERIAL ANDMETHODS:
Three Wistar adult male rats were studied in three different protocols no fasting group, fasting group over a period of 12 hr before the study with only water provided ad libitum, and fasting group by the same time receiving an oral 50% glucose solution. Thirty-minute acquisition images were obtained with a micro-PET, thirty and sixty minutes after the administration of 370-555 MBq 18F-FDG. Comparative and visual analysis were performed by two experts in the field.RESULTS:
Eigtheen studies were analyzed, six per group. The best images were those of the first group, especially those taken at 60 minutes after the 18F-FDG administration.CONCLUSION:
It is possible to establish the non-fasting protocol for the assessment of myocardial metabolism to be used in the future for the myocardial viability evaluation in ischemic cardiopathy.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Compostos Radiofarmacêuticos
/
Tomografia por Emissão de Pósitrons
/
Coração
/
Miocárdio
Limite:
Animais
País/Região como assunto:
México
Idioma:
Espanhol
Revista:
Arch. cardiol. Méx
Assunto da revista:
Cardiologia
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Universidad Nacional Autónoma de México/MX
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