Arritmias y muerte súbita en la taquicardia ventricular catecolaminérgica de origen hereditario / Ventricular arrhythmias of catecholaminergic origin and sudden death
Arch. cardiol. Méx
;
77(supl.4): S4-175-S4-177, oct.-dic. 2007.
Artigo
em Espanhol
| LILACS
| ID: lil-568696
ABSTRACT
The hereditary disease known as polymorphic catecholaminergic ventricular tachycardia (PCVT) is highly lethal. Almost 30% of the affected patients die before 40 years old, mainly due to sudden cardiac death. We have used isolated hearts from mutant mice (type 2 ryanodine receptors, RyR2/RyR2(R4496C)) to investigate arrhythmia mechanisms that are adrenergic- and intracellular calcium ([Ca2+]o) levels-dependent. Our results corroborate that polymorphic and bidirectional ventricular arrhythmias, as well as ventricular fibrillation, occurs in 50% of RyR2/ RyR2(R4496C) mice, and in less than 12% of the non-affected mice. Our hypothesis suggests that the origin of catecholaminergic arrhythmias in animals, and possibly in humans, is conditioned by the focal activity that begins by late post-potentials in the Purkinje fibers.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Arritmias Cardíacas
/
Morte Súbita Cardíaca
/
Receptores de Catecolaminas
Limite:
Animais
Idioma:
Espanhol
Revista:
Arch. cardiol. Méx
Assunto da revista:
Cardiologia
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
SUNY Upstate Medical University/US
Similares
MEDLINE
...
LILACS
LIS