Histopatología de la pulpa de dientes de ratones sometidos a la acción de medicamentos utilizados en las terapias pulpares de dientes deciduos humanos / Histopathology of the pulp of mouse teeth subjected to the action of drugs used in pulp therapy of deciduous human teeth

RESUMEN

En el presente trabajo se utilizaron 18 ratones (Wistar) distribuídos en 3 ratones por cada grupo experimental (24 horas, 3,7,14, 28 Y 90 días); estos animales fueron sometidos a una exposición pulpar, de los primeros molares superiores e inmediato recubrimiento con dos pastas a base de iodoformo, paramonoclorofeno alcanforado y Rifocort, además de hidróxido de calcio y óxido de zinc como productos modificadores en la pasta denominada como "experimental". Luego de los correspondientes procedimientos laboratoriales y obtención de los cortes histológicos para el estudio al microscopio de luz se pudo concluir que de una forma general las dos pastas son bien toleradas en el tejido conjuntivo de la pulpa de dientes de ratones.

ABSTRACT

In this reseach 18 rats (Wistar strain) were used divided in 3 animals for each experimental period of time previusly stabilited as 24 hours, 3, 7, 14, 28 and 90 days. In these animals a pulpal exposure was practicede the in upper first molars followed by imediat pulp capping with the paste being now proposed (experimental paste) or with one suggent by Guedes-Pinto &. Cols, 1981 (control paste). After the experimental times elapred the animals were sacrificed and have their maxillae extracted for 7 um thick slides be made amd were dyed by means hematoxilin and eosin technique to be examined at the ligtht miscroscope. From the histologic examination was posible to conlude tha both pastes were well tolerated by the conective pulpal tissue of the rat molars, since a discreta inflatory reaction was found for time intervals of 24 hours and 3 days. For the 7 days observation period the initial formation of dentin bridge was seen that at op days was completely forme up to well as the periapical tissue have shown histologig characterristics of normality. The reseach has shown that the addition of calcium hydoxide and zinc oxide to the control paste did not modify the histo-pathology reactions of rats pulpal tissue.