Triterpenos aislados de corteza de Bursera graveolens (Burseraceae) y su actividad biologica

RESUMEN

Bursera graveolens (Burseraceae), known in Colombia as "sasafrás", is useful for its medicinal properties and is rich in secondary metabolites. In our research, we carried out antimicrobial tests of several fractions and ethanolic extracts from aerial parts against Bacillus subtilis and Staphylococcus aureus, that showed growth inhibitory activity when applied at 250 mg/mL for extracts and 150 mg/mL for fractions. We carried out an antiinflamatory assay also, that showed 71 por ciento of inhibition by extracts (81 por ciento of Indomethacin) and 70 por ciento of inhibition by fractions (78 por ciento of Indomethacin). Phytochemical investigation of the bark of Bursera graveolens (Burseraceae) yielded three tetracyclic triterpene acids that have oxygenation in C-3, carboxylic acid in C-21 and unsaturation in C-24 and have been identified as 3-oxotirucalla-8,24-dien-21-oic acid (b-elemonic acid), 3a-hydroxytirucalla-8,24-dien-21-oic acid (a-elemolic acid) and 3a-hydroxytirucalla-7,24-dien-21-oic acid. The isolated compounds were identified using spectroscopic methods including one and two-dimensional Nuclear Magnetic Resonance (COSY, HMQC, HMBC, NOESY) experiments and comparison with published data. This is the first report of the isolated compounds in Bursera graveolens and they have a very important chemotaxonomic significance within the Burseraceae family and related families from the order Rutales.