Cytoprotective and suicidal signaling in oxidative stress
Biol. Res
;
43(3): 363-369, 2010. ilus
Artigo
em Inglês
| LILACS
| ID: lil-571999
ABSTRACT
Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (i) the development of an acute and mild pro-oxidant state by thyroid hormone administration eliciting the redox upregulation of the expression of proteins affording cell protection as a preconditioning strategy against ischemia-reperfusion liver injury; and (ii) the role of prolonged and severe oxidative stress and insulin resistance as determinant factors in the pathogenesis of non-alcoholic fatty liver disease associated with obesity.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hormônios Tireóideos
/
Resistência à Insulina
/
Traumatismo por Reperfusão
/
Estresse Oxidativo
/
Citoproteção
/
Fígado Gorduroso
/
Obesidade
Limite:
Humanos
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2010
Tipo de documento:
Artigo
/
Documento de projeto
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