Hyaluronan does not improve bone healing in critical size calvarial defects in rats: a radiographic evaluation
Braz. j. oral sci
;
9(2): 124-127, Apr.-June 2010. ilus, tab
Artigo
em Inglês
| LILACS, BBO
| ID: lil-578076
ABSTRACT
Aim:
This study evaluated radiographically the effects of 1% hyaluronan in bone healing using a critical size rat-calvaria defect model.Methods:
Thirty adult male Wistar rats were used in this study. Two 6-mm-diameter critical-size defects were created and the treatments were randomly distributed as follows 1) 1% hyaluronan; 2) 1% hyaluronan soak loaded onto an absorbable collagen sponge (ACS) carrier; 3) saline; and 4) ACS alone. The animals were sacrificed at 4 and 8 weeks when biopsies were collected and radiographs obtained using a direct digital radiograph system and a standardized protocol. A blind examiner evaluated the radiographic density of the images twice and an intra class correlation was performed to evaluate examiner reproducibility (R2=0.99, p<0.001). Comparisons between 4 and 8 weeks of treatment were performed by Students t test and comparisons between treatments and time by two-way A NOVA at 5% significance level.Results:
There were no noteworthy differences between 4 or 8 weeks within each treatment group (p>0.05). When treatments were compared no significant differences between groups were found (p>0.05).Conclusions:
Within the limits of this study, it can be concluded that 1% hyaluronan gel alone or its association with a carrier does not improve bone healing.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Crânio
/
Materiais Biocompatíveis
/
Regeneração Óssea
/
Densidade Óssea
/
Ácido Hialurônico
Tipo de estudo:
Guia de Prática Clínica
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. oral sci
Assunto da revista:
Odontologia
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
State University of Campinas/BR
/
São Leopoldo Mandic Dental School/BR
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