Evaluación de la histotoxicidad del 2-octyl-cyanoacrilato en el cerebro del conejo / Histotoxicity evaluation of 2-octyl-cyanoacrylate on the rabbit's brain
Rev. chil. neurocir
;
29: 20-24, oct. 2007. tab, ilus
Artigo
em Inglês
| LILACS
| ID: lil-585694
ABSTRACT
The aim of the present study was to evaluate the effect of the 2-octyl-cyanoacrylate, on a rabbit's brain. The study was undertaken to investigate the histological behavior of the brain with this synthetic tissue adhesive. We evaluated a total of 12 rabbits, wich were randomized into 2 groups of 6 rabbits each. Following fronto-temporo-parietal craniectomy, 1 cm of the cranium was removed and the dura mater was 0,5 cm sectioned. In the control group, dura mater was sutured with 6-0 polypropylene interrupted sutures. In the study group, the brains were covered by using 2-octyl-cyanoacrylate (high viscosity), before closurewith 6-0 polypropylene suture. Rabbits were sacrificed on day 7 following operation. Integrity of the sutures, existence of abscess, wound infection and adhesion formation were recorded. The heads were removed including the site of operation and then, the specimens were sent for histological examination. Mean weights of each study group increased. The body temperatures of the animals were normal in the two groups. The histopathological evaluation of the brains treated with the synthetic glue revealed 50 per cent of inflammatory response with focal necrosis in the cortex. Only one rabbit had a normal brain. Results under experimental conditions, indicate that this new substance, 2-octyl-cyanoacrylate, can not be considered as safe supportive material for intradural procedures directly involving the brain tissue.
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Índice:
LILACS (Américas)
Assunto principal:
Polímeros
/
Adesivos Teciduais
/
Cianoacrilatos
/
Cérebro
Tipo de estudo:
Estudos de avaliação
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. chil. neurocir
Assunto da revista:
Neurocirurgia
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
PROMEDICA/BR
/
Universidade Federal da Paraiba/BR
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