Regulatory elements involved in the post-transcriptional control of stage-specific gene expression in Trypanosoma cruzi: a review
Mem. Inst. Oswaldo Cruz
;
106(3): 257-266, May 2011. ilus
Artigo
em Inglês
| LILACS
| ID: lil-589032
ABSTRACT
Trypanosoma cruzi, a protozoan parasite that causes Chagas disease, exhibits unique mechanisms for gene expression such as constitutive polycistronic transcription of protein-coding genes, RNA editing and trans-splicing. In the absence of mechanism controlling transcription initiation, organized subsets of T. cruzi genes must be post-transcriptionally co-regulated in response to extracellular signals. The mechanisms that regulate stage-specific gene expression in this parasite have become much clearer through sequencing its whole genome as well as performing various proteomic and microarray analyses, which have demonstrated that at least half of the T. cruzi genes are differentially regulated during its life cycle. In this review, we attempt to highlight the recent advances in characterising cis and trans-acting elements in the T. cruzi genome that are involved in its post-transcriptional regulatory machinery.
Texto completo:
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Índice:
LILACS (Américas)
Assunto principal:
Transcrição Gênica
/
Trypanosoma cruzi
/
RNA Mensageiro
/
Processamento Pós-Transcricional do RNA
/
Regulação da Expressão Gênica no Desenvolvimento
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Minas Gerais/BR
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