Benznidazole levels in blood vary with age in rats
Mem. Inst. Oswaldo Cruz
;
106(3): 374-377, May 2011. tab
Artigo
em Inglês
| LILACS
| ID: lil-589051
ABSTRACT
Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Tripanossomicidas
/
Microssomos Hepáticos
/
Cromatografia Líquida de Alta Pressão
/
Nitroimidazóis
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
Institute of Scientific and Technological Research of the Armed Forces/AR
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