Glycolipids from macroalgae: potential biomolecules for marine biotechnology?
Rev. bras. farmacogn
;
21(2): 244-247, mar.-abr. 2011. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-590180
ABSTRACT
Brown, red and green algae from the Southeastern coast of Brazil were successively extracted with chloroform/methanol 21 and 12 (v/v). The crude lipid extract was partitioned according to Folch and the lower phase enriched in glycolipids was fractionated on a silica gel column chromatography eluted with chloroform, acetone and methanol. Three major orcinol-reactive bands present in the acetone and methanol fractions were detected by thin-layer chromatography with chromatographic mobilities corresponding to sulfoglycolipids and glycosyldiacylglycerols. These fractions exhibited potent antiviral activity against HSV-1-ACVs and HSV-1-ACVr and present low toxicity for cell cultures. Purification and identification of these bioactive glycolipids will be necessary in order to elucidate their primary structures and mechanism of action.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Idioma:
Inglês
Revista:
Rev. bras. farmacogn
Assunto da revista:
Farmácia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Paraná/BR
/
Universidade Federal do Rio de Janeiro/BR
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