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Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
Llanos, Carolina; Carreño, Leandro J; Kalergis, Alexis M.
  • Llanos, Carolina; Pontificia Universidad Católica de Chile. , Facultad de Ciencias Biológicas. Departamento de Genética Molecular y Microbiología. Millennium Nucleus on Immunology and Immunotherapy. CL
  • Carreño, Leandro J; Pontificia Universidad Católica de Chile. , Facultad de Ciencias Biológicas. Departamento de Genética Molecular y Microbiología. Millennium Nucleus on Immunology and Immunotherapy. CL
  • Kalergis, Alexis M; Pontificia Universidad Católica de Chile. , Facultad de Ciencias Biológicas. Departamento de Genética Molecular y Microbiología. Millennium Nucleus on Immunology and Immunotherapy. CL
Biol. Res ; 44(1): 53-61, 2011. ilus
Artigo em Inglês | LILACS | ID: lil-591864
ABSTRACT
Under healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host tissues. The mechanisms conducing to the loss of immune tolerance remain largely unknown. The recent appearance of biological therapies has contributed to significant reduction in morbidity. However, currently available therapies are associated with important side effects and work only as palliative treatments. Dendritic cells (DCs) have emerged as key players in developing and maintaining adaptive immunity due to their capacity to prime and modulate T cell function. Therefore, because DCs work as central modulators of immune tolerance, it is likely that alterations in their function can lead to the onset of autoimmune-inflammatory diseases. By modulating DC function, novel pathways in antigen-specific tolerance could be established. In this article, the possible contribution of altered DC-T cell interactions to the onset of autoimmunity are discussed. In addition, we expand on the notion that some of the functions of these cells could be relevant targets for intervening therapies aimed to restore the balance or even prevent the loss of tolerance.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Doenças Autoimunes / Células Dendríticas / Linfócitos T / Autoimunidade / Comunicação Celular Limite: Humanos Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Pontificia Universidad Católica de Chile/CL

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Doenças Autoimunes / Células Dendríticas / Linfócitos T / Autoimunidade / Comunicação Celular Limite: Humanos Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Pontificia Universidad Católica de Chile/CL