Pharmacokinetics of cephalosporins in the neonate: a review
Clinics
;
66(7): 1267-1274, 2011. tab
Artigo
em Inglês
| LILACS
| ID: lil-596919
ABSTRACT
The aim of this work was to review the published data on the pharmacokinetics of cephalosporins in neonates to provide a critical analysis of the literature as a useful tool for physicians. The bibliographic search was performed for articles published up to December 3, 2010, using PubMed. In addition, the book Neofax: A Manual of Drugs Used in Neonatal Care by Young and Mangum was consulted. The cephalosporins are mainly eliminated by the kidneys, and their elimination rates are reduced at birth. As a consequence, clearance is reduced and t1/2 is more prolonged in the neonate than in more mature infants. The neonate's substantial body water content creates a large volume of distribution (Vd) of cephalosporins, as these drugs are fairly water soluble. Postnatal development is an important factor in the maturation of the neonate, and as postnatal age proceeds, the clearance of cephalosporins increases. The maturation of the kidney governs the pharmacokinetics of cephalosporins in the infant. Clearance and t1/2 are influenced by development, and this must be taken into consideration when planning a cephalosporin dosage regimen for the neonate.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cefalosporinas
/
Rim
/
Antibacterianos
Limite:
Humanos
/
Lactente
/
Recém-Nascido
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Itália
Instituição/País de afiliação:
University of Pisa/IT
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