Experimental Tityus serrulatus scorpion envenomation: age- and sex-related differences in symptoms and mortality in mice
J. venom. anim. toxins incl. trop. dis
;
17(3): 325-332, 2011. ilus, graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-597232
ABSTRACT
Among the various methods for evaluating animal venom toxicity, the calculation of the median lethal dose (LD50) is the most widely used. Although different protocols can be used to calculate the LD50, the source of the venom and the method of extraction, as well as the strain, age, and sex of the animal model employed, should be taken into consideration. The objective of the present study was to evaluate the influence of sex and age on the toxicity of Tityus serrulatus scorpion venom in Swiss mice. Although the symptoms of envenomation were similar in male and female animals, female mice proved to be more resistant to the venom. In females, age had no impact on the susceptibility to scorpion envenomation. Male mice were more sensitive to T. serrulatus venom. Moreover, in males, age was an important parameter since sensitivity to the venom increased with age.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Venenos de Escorpião
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2011
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
University of São Paulo (USP)/BR
/
University of São Paulo/BR
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