Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal / Hypovitaminosis D in pediatric patients on renal replacement therapy
Rev. méd. Chile
;
139(3): 334-339, mar. 2011. ilus
Artigo
em Espanhol
| LILACS
| ID: lil-597622
ABSTRACT
Background:
Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD).Aim:
To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation. Material andMethods:
Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 ± 4.6 years (51 percent females).Results:
Fifty four percent of patients had height Z score less than -1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 ± 2.8 years. Mean 25(OH)D levels in all was 18.7 ± 10.7ng/ml (HD 21 ± 16.8, PD 18.9 ± 8.5, Tx 18.1 ± 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 ± 0.64 mg/dl, serum phosphorus 5.03 ± 1.02 mg/dl, calcium-phosphorus product 48 ± 11.8 mg/dl and alkaline phosphatases 300.5 ± 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 ± 640.5 and 107.7 ± 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH) D and calcium levels among PD patients was observed (r = 0.490, p = 0.04).Conclusions:
Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Deficiência de Vitamina D
/
Terapia de Substituição Renal
/
Falência Renal Crônica
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad de Chile/CL
/
Universidad de Chile, Hospital Luis Calvo Mackenna/CL
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