Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
Mem. Inst. Oswaldo Cruz
;
106(5): 617-619, Aug. 2011. ilus, graf
Artigo
em Inglês
| LILACS
| ID: lil-597723
ABSTRACT
The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Strongyloides
/
Estrongiloidíase
/
Enteropatias Parasitárias
/
Mycobacterium bovis
/
Infecções por Mycobacterium
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Juiz de Fora/BR
/
Universidade Federal de Minas Gerais/BR
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