Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
Clinics
;
66(8): 1437-1442, 2011. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-598401
ABSTRACT
OBJECTIVES:
To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction.INTRODUCTION:
Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury.METHODS:
Male Wistar rats were divided into four groups control-sham, diabetes-sham, myocardial infarction, and diabetes + myocardial infarction. Myocardial infarction was induced 14 days after diabetes induction. Ventricular function and morphometry, as well as oxidative stress and hemodynamic parameters, were evaluated after seven days of myocardial infarction.RESULTS:
The myocardial infarction area, which was similar in the infarcted groups at the initial evaluation, was reduced in the diabetes + myocardial infarction animals (23 ± 3 percent) when compared with the myocardial infarction (42 ± 7 percent, p<0.001) animals at the final evaluation. The ejection fraction (22 percent, p = 0.003), velocity of circumferential fiber shortening (30 percent, p = 0.001), and left ventricular isovolumetric relaxation time (26 percent, p = 0.002) were increased in the diabetes + myocardial infarction group compared with the myocardial infarction group. The diabetes-sham and diabetes + myocardial infarction groups displayed increased catalase concentrations compared to the control-sham and myocardial infarction groups (diabetes-sham 32± 3; diabetes + myocardial infarction 35± 0.7; control-sham 12 ± 2; myocardial infarction 16 ± 0.1 pmol min-1 mg-1 protein). The levels of thiobarbituric acid-reactive substances were reduced in the diabetes-sham rats compared to the control-sham rats. These positive adaptations were reflected in a reduced mortality rate in the diabetes + myocardial infarction animals (18.5 percent) compared with the myocardial infarction animals (40.7 percent, p = 0.001).CONCLUSIONS:
These data suggest that short-term hyperglycemia initiates compensatory mechanisms, as demonstrated by increased catalase levels, which culminate in improvements in the ventricular response, infarcted area, and mortality rate in diabetic rats exposed to ischemic injury.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Disfunção Ventricular Esquerda
/
Estresse Oxidativo
/
Diabetes Mellitus Experimental
/
Hiperglicemia
/
Infarto do Miocárdio
Limite:
Animais
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Argentina
/
Brasil
Instituição/País de afiliação:
Nove de Julho University/BR
/
São Judas Tadeu University/BR
/
Universidad de Buenos Aires/AR
/
University of São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS