Characterization of a new Kinin potentiating peptide obtained from human plasma proteins
Braz. j. med. biol. res
;
21(3): 453-5, Mar. 1988. tab
Artigo
em Inglês
| LILACS
| ID: lil-60218
ABSTRACT
Partially purified kinin potentiating peptide (KPP) obtained from kininogen-depleted human plasma inhibited lung angiotensin converting enzyme in vitro and potentiated guinea-pig ileum contractions induced by bradykinin (BK), Lys-BK, Met-Lys-BK, Ile-Ser-BK, and Lys-Lys-BK. Contractions evoked by angiotensin II, histamine, acetylcholine, and barium cloride were not potentiated. KPP also potentiated kinin-induced contractions of rat uterus and of guinea-pig ileum pre-incubated with 1,10-phenbabthroline. It in suggested that KPP potentiation is due, at least in part, to a direct effect on kinin receptor(s)
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Índice:
LILACS (Américas)
Assunto principal:
Técnicas In Vitro
/
Proteínas Sanguíneas
/
Cininas
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
/
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