Characterization of adrenergic control of the Leydig cell steroidogenesis: identification of both stimulatory and inhibitory components
Braz. j. med. biol. res
;
21(3): 539-43, Mar. 1988. ilus
Artigo
em Inglês
| LILACS
| ID: lil-60249
ABSTRACT
Percoll-purified Leydig cells were studied in vitro in order to evaluate the effect of adrenaline on testosterone (T) secretion. Adrenaline enhanced the basal and potentiated the hCG-induced T release. A similar effect was also obtained with the ß2-agonist, salbutamol. Although phenyleprine, an alfa1-agonist, did not alter the basal T secretion, it enhanced hCG-mediated T secretion. Para-aminoclonidine, an alfa2-agonist, decreased the basal T release without altering the HCG-stimulated T release. These data demonstrate that either inhibitory or stimulatory effects on T release can be obtained and that they depend on the adrenoreceptor subtype involved
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Índice:
LILACS (Américas)
Assunto principal:
Testosterona
/
Técnicas In Vitro
/
Epinefrina
/
Receptores Adrenérgicos
/
Gonadotropina Coriônica
/
Células Intersticiais do Testículo
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
/
Congresso e conferência
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