The effect of diphenylhydantoin on spreading depression
Braz. j. med. biol. res
;
21(3): 603-5, Mar. 1988. tab
Artigo
em Inglês
| LILACS
| ID: lil-60253
ABSTRACT
The present study examines the effect of diphenylhydantoin on the elicitation by K+ and propagation of spreading depression in chick retina preparations in vitro. A dose-related decrease in the velocity of propagation was observed, this effect being lessened by increasing the pH of the Ringer bathing the preparation. Changes in Ringer C1- concentration also altered the efficacy of the drug, higher concentrations enhancing and lower concentrations reducing efficacy. The threshold concentration of K+ necessary to elicit the reaction was elevated by dyphenylhydantoin
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Índice:
LILACS (Américas)
Assunto principal:
Fenitoína
/
Potássio
/
Retina
/
Depressão Alastrante da Atividade Elétrica Cortical
/
Técnicas In Vitro
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
/
Congresso e conferência
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