A new mechanism of action of dipyrone: blockade of the release of a nociceptive factor from macrophages
Braz. j. med. biol. res
;
21(3): 565-8, Mar. 1988. ilus
Artigo
em Inglês
| LILACS
| ID: lil-60264
ABSTRACT
Rat macrophage monolayers pre-treated with endotoxin release into the incubating fluid a factor (MW >10,000) capable of inducing writhing in mice (MNF). This release was inhibited by dipyrone (3.5-35 microng/ml) but not by indomethacin (0.5-2 microng/ml). Writhing in mice induced by the factor is blocked by dipyrone (0.5-50 mg/kg) and indomethacin (0.5-2 mg/kg). These results indicate that in addition to the previously described direct blockade of hyperalgesia by dipyrone, this drug may also affect the release of MNF, wich induces in vivo nociception through the release of prostaglandin-like substances
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Índice:
LILACS (Américas)
Assunto principal:
Nociceptores
/
Dipirona
/
Indometacina
/
Macrófagos
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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