Peripheral modulation of pain in conscions guinea pigs: effect of morphine nalorphine and clonidine
Braz. j. med. biol. res
;
21(3): 577-83, Mar. 1988. ilus
Artigo
em Inglês
| LILACS
| ID: lil-60268
ABSTRACT
Morphine and nalorphine were shown to have a peripheral effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. Naloxone antagonized the effect of morphine and nalorphine. Locally administered clonidine had a peripheral effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. The peripheral analgesia of clonidine was antagonized by yohimbine and naloxone. The analgesic effect clonidine was 250-300 times more potent than that of lidocaine. It is suggested that alfa2-adrenergic receptor agonists may active enkephalin-like substances released at the peripheral level
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Índice:
LILACS (Américas)
Assunto principal:
Vocalização Animal
/
Medição da Dor
/
Clonidina
/
Relação Dose-Resposta a Droga
/
Estimulação Elétrica
/
Analgesia
/
Injeções Subcutâneas
/
Morfina
/
Nalorfina
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
/
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