Aterosclerosis en sujetos con periodontitis / Association between atherosclerosis and periodontitis
Rev. méd. Chile
;
139(6): 717-724, jun. 2011. ilus
Artigo
em Espanhol
| LILACS
| ID: lil-603116
ABSTRACT
Background:
Chronic infl ammation and infections are involved in the development and progression of atherosclerotic vascular disease.Aim:
To evaluate the association between periodontitis and early atherosclerosis. Material andMethods:
Fifty-three subjects who received periodontal treatment and regular maintenance for at least 10 years, and 55 subjects with periodontitis but without a history of periodontal treatment were studied. Carotid artery intima-media wall thickness (CIMT) was measured with high-resolution B-mode ultrasonography. A blood sample was obtained to measure high sensitivity C-reactive protein, fibrinogen, lipoprotein cholesterol, leukocyte count and erythrocyte sedimentation rate. Covariates included age, gender, smoking, level of education, body mass index and physical activity. The benzoyl-DL-arginine-naphthylamide (BANA) test was used to determine the number of periodontal sites with periodontal pathogens.Results:
CIMT value was significantly higher in subjects with periodontitis than those without it (0.775 ± 0.268 and 0.683 ± 0.131 mm respectively, p = 0.027). C-reactive protein, leukocyte count and percentage of sites with periodontal pathogens were also significantly higher in subjects with periodontitis. Regression analysis identified age, periodontitis, and smoking as independent predictors of CIMT.Conclusions:
These results suggest that untreated periodontitis is associated with early atherosclerotic carotid lesions and higher levels of infl ammatory markers.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Periodontite
/
Mediadores da Inflamação
/
Aterosclerose
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Clínica Santa María/CL
/
Universidad de Chile+CL
/
Universidad de Chile/CL
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